Dietary patterns high in fruits and vegetables have been associated with lower risk of cardiovascular diseases. The association between phylloquinone intake, derived mainly from green vegetables, and risk of cardiovascular diseases [total and fatal coronary heart disease (CHD), non-fatal myocardial infarction, total and ischemic stroke] was prospectively assessed in 40087 men who participated the Health Professionals’ Follow-up Study during 1986-2000. There were 1857 CHD events and 617 strokes. After adjustment for lifestyle factors, the relative risks of CHD in increasing quintile categories of phylloquinone intake were 1 (reference), 0.84, 0.87, 0.82 and 0.84, respectively (P for trend 0.05). However, the risks of CHD events and strokes did not remain significantly associated with phylloquinone intake after adjustment for lifestyle and other dietary factors. These results suggest that high phylloquinone intake may be a marker of a diet that is associated with lower CHD risk, but has little or no independent association.